Understanding Transthyretin Amyloid Cardiomyopathy
Amyloidosis is a multisystemic disease in which TTR proteins with unstable structures misfold and aggregate into amyloid fibrils, which deposit in the heart and other organs.1 The most common amyloid fibril proteins that can infiltrate the heart and lead to cardiac amyloidosis1 are immunoglobulin light chain amyloid fibril protein (AL) and transthyretin amyloid fibril protein (ATTR).2-5
Most Common Types of Cardiac Amyloidosis
ATTR amyloidosis5
AL amyloidosis5
Wild-type ATTR (wtATTR)5
Hereditary ATTR (hATTR)1
Also known as variant1
Learn more
It is important to clinically differentiate between ATTR and AL, as they have different clinical courses,5
and AL requires immediate treatment.6
Once diagnosed, untreated patients with ATTR-CM have a median survival of ~2 to 3.5 years


Illustrative representation.
EARLY DIAGNOSIS OF
MAIN TYPES OF CARDIAC AMYLOIDOSIS
It is important to clinically differentiate between
Most Common Types of Cardiac Amyloidosis
ATTR-CM5
AL amyloidosis5
Wild-type ATTR-CM (wtATTR-CM)5
Hereditary ATTR-CM (hATTR-CM)1
Wild-type vs HEREDITARY
Wild-type
Hereditary
*Also known as variant ATTR.1
Wild-type
Patient Considerations
- Ethnicity: predominantly white7,8
- Mostly men7,8,10
- Symptom onset typically over the age of 60 years11
- Heart failure7,8,10
- Cardiac arrhythmias,
particularly atrial fibrillation3,7,8,10 - History of bilateral carpal
tunnel syndrome7,10,12
Prognosis
- Median survival: ~3.5 years7,10,13
Hereditary
Patient Considerations
- African American, African,
or Afro-Caribbean descent (V122I)3,8 - Irish descent (T60A)3
- Men and women8
- Symptom onset may occur as early as 50-60 years of age11,16
- Heart failure8
- Neurological symptoms
(peripheral and autonomic)8 - Gastrointestinal symptoms8
- History of bilateral carpal
tunnel syndrome8
Prognosis
- Median survival: ~2 to 3 years3
wtATTR IS THOUGHT TO ACCOUNT FOR THE MAJORITY OF
Encountering ATTR-CM
Meet Dr. Detective, a cardiologist who specializes in diagnosing tough cases. Watch as he suspects and then detects that his patient has
MECHANISM OF DISEASE
In ATTR-CM, TTR proteins with unstable structures misfold and aggregate into amyloid fibrils, which deposit in the heart and other organs.1,4


Illustrative representation.
Amyloid body of Evidence (ABE) Is Here To show you some of the clues that should Raise your suspicion of ATTR-CM
Meet ABE. Looking at this model, you can see some common ATTR deposition sites and how ATTR amyloidosis can lead to ATTR-CM.



Amyloid Body of Evidence (ABE) is an artistic representation.
ATTR, transthyretin amyloid fibril protein; ATTR-CM, transthyretin amyloid cardiomyopathy.
© 2021 Pfizer Inc. All rights reserved. September 2021 PP-R1D-USA-0850
EARLY, ACCURATE DIAGNOSIS OF
Know the clues to look for to avoid missing a diagnosis. Learn the clues
ENCOUNTERING
Meet Dr. Detective, a cardiologist who specializes in diagnosing tough cases. Watch as he suspects and then detects that his patient has