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Detect Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Discover the tools to diagnose ATTR-CM

See how nuclear scintigraphy, endomyocardial biopsy (EMB), and genetic testing can support or inform an ATTR-CM diagnosis

*Should be combined with blood and urine testing to rule out AL.1,2

Making an ATTR-CM Diagnosis

Watch a cardiologist diagnose ATTR-CM.

In the previous videos, Dr. Detective had a patient referred to him. He suspected ATTR-CM based on certain signs and symptoms. See what happens next.


A diagnostic algorithm

For patients with suspected Attr-cm2

Below is an algorithm that was proposed to aid in determining the appropriate diagnostic tool for detecting suspected ATTR-CM

Dignostic Algorithm
Dignostic Algorithm

IFE, immunofixation; SPEP, serum protein electrophoresis; UPEP, urine protein electrophoresis.

*If clinical suspicion remains high for cardiac amyloidosis in spite of a negative 99mTc-PYP scan, biopsy may be considered to evaluate for other types of infiltrative cardiomyopathy (eg, amyloid A).

Also known as variant ATTR.8


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